Customization: | Available |
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Certification: | RoHS, BRC, ISO, FDA, HACCP |
Assay Method: | HPLC |
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[ Product Name ] Diosmin 90%
[ Appearance ] Greyish-yellow or light-yellow hygroscopic powder
[ Active Ingredients ] Diosmin 90%
[ Shelf Life ] 2 years if sealed and store away from direct sun light.
[ Main Functions ]
A flavonoid found in citrus fruits and an agonist of the aryl hydrocarbon receptor (AhR).
Mechanism
1. Enhancing venous tension Diosmin enhances venous wall tension, even under high temperature. It causes a stronger venous contraction than other drugs such as rutin. It can still enhance venous tension when the body is in acidosis. . Diosmin has a specific affinity for veins without affecting the arterial system.
2. Improve microcirculation diosmin can significantly reduce the adhesion, migration, disintegration and release of inflammatory substances, such as histamine, bradykinin, complement, leukotrienes, prostaglandins and excessive Free radicals, etc., thereby reducing the permeability of capillaries and enhancing their tension, diosmin also has the function of reducing blood viscosity and enhancing the flow rate of red blood cells, thereby reducing microcirculation stasis.
3. Promote lymphatic return diosmin increases the speed of lymphatic drainage
------------------------------- Certificate of Analysis----------------------------
Analysis Item |
Specification |
Result |
Method |
Appearance | Greyish-yellow or light-yellow hygroscopic powder. | Complies | Visual |
Identification[a,b] | Must positive | Positive | IR / HPLC |
Solubility | Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides. | Complies | Visual |
Residual solvent -Solvent A |
≤300ppm | <300ppm | HPGC |
Iodine | ≤0.1% | <0.1% | Potentiostat |
Related substances (Impurity By HPLC) | |||
A: acetoisovanillone | ≤0.5 % | 0.08% | HPLC |
B: hesperidin | ≤4.0 % | 1.12% | HPLC |
C: isorhoifolin | ≤3.0 % | 2.66% | HPLC |
D:6-iododiosmin | ≤0.6% | 0.23% | HPLC |
E: linarin | ≤3.0 % | 1.76% | HPLC |
F: diosmetin | ≤2.0 % | 0.96% | HPLC |
Unspecified impurities | ≤0.4% | 0.17% | HPLC |
Total | ≤8.5 % | 7.65% | HPLC |
Sulfated ash | ≤0.2% | 0.10% | EP9.0 |
Water | ≤5.0% | 2.50% | Karl Fischer |
Particle size | 100% through 80 mesh | Complies | 80 Mesh Screen |
Assay by HPLC | 90.0% -102.0% | 92.40% | HPLC |
Microbiological test | |||
Total plate count | ≤1000 cfu/g | <20cfu/g | EP9.0 |
Mildew & Yeast | ≤100 cfu/g | <20cfu/g | EP9.0 |
E.Coli | Negative | Negative | EP9.0 |
Salmonella | Negative | Negative | EP9.0 |
Coliforms | Negative | Negative | EP9.0 |